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CCR9
Chemotactic cytokines or chemokines bind to G protein-coupled receptors and mediate multiple biological functions, including leukocyte adhesion and extravasation. There is a strong association between the expression of certain chemokine receptors on tumor cells and cancer progression, metastasis development and poor prognosis.
Chemokine receptor 9, CCR9, is naturally expressed in the thymus and crypts of the small intestine.
CCR9 expression has been shown to be associated with early recurrence and increased metastatic capacity in solid tumors such as pancreatic and ovarian cancer.
On the other hand, in hematological tumors such as T-cell acute lymphoblastic leukemia (T-ALL), CCR9 is overexpressed and is associated with increased metastatic potential and tumor chemoresistance.
CCR9 Program. Scientific Evidence
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CCR9 as a novel target in solid tumors
- CCR9 has been proposed as a promising immuno-oncology target in different solid tumors.
- CCR9 overexpression is associated with highly metastatic stages of pancreatic cancer.
- Soluble CCR9 overexpression is associated to invasive stages in certain solid tumors including breast, lung, and ovary cancer.
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CCR9 is overexpressed in different blood neoplasias
- Analysis in blood or bone marrow samples, from patients suffering from different types of blood neoplasia has shown CCR9 overexpression in up to 80% of the patients analyzed, including T-ALL and Non-Hodgkin Lymphoma.
Anti-CCR9 Therapeutic Antibodies
SunRock,in collaboration with CIB-CSIC, has developed anti-CCR9 humanized antibodies that show ADCC and CDC-driven antitumor activity, both in vitro and in vivo, with improved affinity to a new and exclusive human CCR9 epitope.
Mice tumors treated with anti-CCR9 antibodies showed increased apoptosis and necrosis and reduced angiogenesis and cell proliferation (Chamorro et al. 2014, Somovilla-Crespo et al. 2018).
SunRock Biopharma owns exclusive, world-wide rights of the IP protecting the CCR9-targeted antibodies.
SunRock’s lead asset, SRB1, is a first-in-class anti-CCR9 antibody, which has shown high efficacy to treat T-ALL and pancreatic cancer in preclinical models.
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SRB1 showed in vivo Efficacy: Pancreatic Cancer
- Complete tumor regression in humanized animal models in which tumors derived from pancreatic cancer patients were implanted.
- Improved therapeutic efficacy compared to conventional chemotherapeutic treatments and pembrolizumab
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SRB1 showed in vivo Efficacy: T-ALL Circulating Cell Model
- Complete tumor regression in T-ALL models.
- Increased survival rate compared with standard of care chemotherapeutics.
- No toxicity symptoms in any of the animal models tested
Anti-CCR9 Pipeline
SRB1 (hematologic tumors)
Discovery
Preclinical
Clinic phases
SRB1 (solid tumors)
Discovery
Preclinical
Clinic phases
