Chemotactic cytokines or Chemokines are a family of proteins that bind to G protein-coupled receptors. Chemokines mediate a wide range of biological functions, among them leukocyte adhesion and extravasation. There is a strong association between tumour cell expression of certain Chemokine receptors and cancer progression, development of metastasis and poor prognosis.

Chemokine Receptor 9, CCR9, is naturally expressed in the thymus and the crypts of the small bowel, but it is also overexpressed by CD4+ T-helper cells in T-cell Acute Lymphoblastic Leukaemia (T-ALL), while its expression in normal T-helper cells is very rare and low. CCR9 ligand, CCL25, enhances leukaemic T-cell proliferation.

The Xunta de Galicia, through the program Conecta Peme financed with funds from the European Union, and within its objectives of promoting technological development, innovation and quality research, funds the development and molecular and functional characterization of therapeutic antibodies against CCR9 undertaken by SunRock Biopharma and its corresponding biomarkers of patient selection.

SunRock Biopharma S.L.

Edificio CIMUS. Avenida Barcelona, s/n

15782 Santiago de Compostela. A Coruña. (España)

Tlfno.: +34 881 975 523

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